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KMID : 0043319890120030149
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Archives of Pharmacal Research
1989 Volume.12 No. 3 p.149 ~ p.153
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Synthesis and Biological Effects of 2,3-Diphenyl-5-Methoxyindole and Substituted Benzophenone Derivatives
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Hishmat OH
El Shabrawy OA/Nakkady SS/Mahmoud SS
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Abstract
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Seven 2,3-diphenyl-5-methoxyindole derivatives were synthesized. The effect of structural variation of these molecules on biological activities was examined. None of the tested compounds was found to be toxic up to 5gm/kg body weight. Four compounds demonstrated smooth muscle relaxant effects and one showed a persistent hypotensive effect. Only the parent compound, 2,3-diphenyl-5-methoxyindole, showed a significant analgesic effect.
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